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Continued Pressure for Alveolar Protection (CPAP Trial)

RECRUITING

The objective of the CPAP Trial is to test whether extending CPAP until 34 weeks' PMA or for at least 2 additional weeks compared to weaning to a nasal canula will decrease the likelihood of bronchopulmonary dysplasia or death at 36 weeks' PMA.

I'm interested

ALL
Up to 7 month(s) old
This study is NOT accepting healthy volunteers

Inclusion Criteria:

  • Gestational age <29 weeks at birth
  • PMA <32 weeks at study entry
  • On treatment with CPAP without a rate in FiO2 <0.25 and PEEP of 4-5 cmH2O
  • Meet stability criteria:
  • If previously intubated must be extubated ≥ 72 hours
  • <3 self-resolving apneas (≤ 20 s) and/or bradycardia (<100 bpm) in any hour over previous 6 hours
  • No episodes of apnea or bradycardia requiring intervention (oxygen/stimulation/bag and mask) for 24 hours
  • Parents/legal guardians consent for enrollment

Exclusion Criteria:

  • Major malformation
  • Neuromuscular condition that affects respiration
  • Terminal illness
  • Decision to withhold or limit support
  • Too sick to participate in opinion of Attending physician
  • Clinical shock, sepsis
  • Planned surgery during study period

DEVICE: CPAP, DEVICE: Nasal Cannula

Bronchopulmonary Dysplasia (BPD)

Continuous Positive Airway Pressure, CPAP

Traci Beiersdorfer - traci.beiersdorfer@cchmc.org
NA
NCT07417111
See this study on ClinicalTrials.gov

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