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32 Study Matches

Assessing Pulmonary Changes in HSCT

This will be an un-blinded, open-label study of children and adults, including those who are being evaluated for or who have undergone HSCT, those with existing respiratory conditions and/or diagnosed gas-exchange impairment, and healthy control volunteers. The participants will be male or female between 3-17 years old (children) and adults age 18 and older. The study objective is to: * To optimize the acquisition of images reflecting the "dissolved-phase" Xe distribution in the pulmonary tissues and blood (Xe gas-exchange MRI). * To develop and test Xe MRI acquisition strategies that separately image alveolar airspace distribution (ventilation), as well as Xe dissolved in pulmonary tissues versus red blood cells (RBCs). * To acquire images of Xe ventilation and dissolved-phase Xe regional distribution in the enrolled participants. * To understand the same-day variability of Xe MRI techniques. * To determine the relationship between Xe MRI and clinical measures such as pulmonary-function-test (PFT) parameters or other biological biomarkers. * To develop and optimize strategies for Xe MRI in young children including those who are unable to follow the inhalation and breath-hold instructions typical of the Xe MRI procedure.

Ashley Borden, MPH - ashley.borden@cchmc.org

ALL
3 years and over
PHASE1
This study is also accepting healthy volunteers
NCT07823036
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Inclusion Criteria:
* Ages 3 years and older
Exclusion Criteria:
* Pregnancy or positive pregnancy test * Baseline oximetry at MRI visit of less than 90% on room air or less than 90% on a previously prescribed dosage of oxygen delivered by nasal cannula. In some cases of cardiorespiratory disease, if the participant is referred to this research study by their treating physician and considered stable for imaging, the cardiorespiratory criteria will be 5% of their clinical baseline. This should be documented in the research record upon referral of a participant that meets this scenario. * Any condition in the opinion of the investigator that would make the participant unable to tolerate the MRI procedure (e.g., neurocognitive delay, behavioral issues). * Standard MRI exclusions (e.g., metal, incompatible implants).
DRUG: Hyperpolarized 129 Xenon
HSCT, Respiratory, Gas Exchange Impairment
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Proton MRI of MSK Disorders

In this research study, the investigators want to learn about new ways to use MRI (Magnetic Resonance Imaging) to take clearer pictures of the lungs. The investigators will be using types of MRI called UTE (Ultra Short Echo Time) and bSSFP (balanced Steady-State Free Precession) as well as traditional MRI. The investigators also want to collect images and health information about lungs that are healthy or those in people with different kinds of lung, muscular, and bone diseases. This collection will help us in the future to better understand lung variations in health and disease.

Ashley Borden, MPH - ashley.borden@cchmc.org

ALL
5 years and over
This study is also accepting healthy volunteers
NCT07845708
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Inclusion Criteria:
* Age ≥ 5 years
Exclusion Criteria:
* History of any comorbidity reviewed at the Screening phone call that, in the opinion of the investigator, might confound the results of the study or pose an additional risk to the subject. * Standard MRI exclusion criteria as set forth by the CCHMC Radiology Department and IRC. * Pregnancy
DIAGNOSTIC_TEST: MRI
Muskuloskeletal Diseases, Healthy, Respiratory
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See this study on ClinicalTrials.gov